• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A device 10 for producing granulate, which provides at least two functional units for at least two differing process steps in the granulation process, characterized in that the device comprises; a modular system of attachments 14 from which the at least two functional units can be composed in dependence on the respective process step. The device may comprise at least one rotatably and/or displaceably mounted plate 12. The plate may comprise receiving means 18 to which the functional units may be attached, the receiving means being movable between at least two positions. The invention furthermore relates to a method for the production of a granulate through use of the device according to the invention.
    公开号:SE1350695A1
    申请号:SE1350695
    申请日:2013-06-07
    公开日:2013-12-21
    发明作者:Wolfgang Szczerba；Matthias Stillhammer；Thomas Brinz；Marcus Knoell
    申请人:Bosch Gmbh Robert；
    IPC主号:
    专利说明:

    Prior art The invention relates to a device for producing granules, wherein the device provides at least two functional units for in all cases at least two different process steps in the granulation process. The invention further relates to a process for the production of granules using such a device.
    In the manufacture of pharmaceutical products, granules are mainly used for further processing, for example for the manufacture of tablets or for filling capsules. Granules then comprise agglomerated powder particles, which have uneven surfaces and internal structures.
    Moisture granulation is usually used in the preparation of such granules. The moisture granulation then takes place in granulators, which in a first step mix a powder mixture with solvents and probe the moist material in a second step, for example by sieving with subsequent drying. Other methods of granulation are, for example, dry granulation, roller compaction or whirlpool granulation.
    Moisture granulation methods and devices are known in the art. DE 18 471 A1 discloses a one-man mixer-granulator-dryer, which is a one-man production machine for successive mixing, moisture granulation and drying of pharmaceutical solid products. In addition, the separate process steps for the preparation of pharmaceutical granules are carried out, such as the mixing, the granulation and the subsequent drying in a container, which as such comprises all necessary details.
    CN 201 437 A describes a modular granulation production line, which comprises a supply module, a granulation main module, an air control module, a screening module and a prefabricated product storage module, and an integrated control module, the separate modules being arranged in a fixed order in the production line. 2 According to the state of the art, although realized devices can be realized in one step or within the framework of a production line for moisture granulation, these have the disadvantage that the handling is very inflexible. Thus, such apparatus, in particular with respect to p5 on a production scale, is limited to mass production. Therefore, parameter investigations (screenings) are only possible at high costs, and such devices are less suitable for laboratory applications to testers51. In order to adapt the amount of raw material, CN 20 143 080 A describes an apparatus for processing powder, in which a removable container with a conical shape is provided in the upper half of the raw material container. However, this design is limited to usable for laboratory use, although despite the possibility of limiting the amount of material, the actual device design remains unchanged.
    Knowing devices for the production of granules are furthermore cumbersome to handle, for example the cleaning of the individual components is cumbersome, since these must first be disassembled. There is therefore a continuing interest in providing devices which provide a flexible and simple in handling construction. In particular, such devices must be suitable for laboratory use and, consequently, the following quantities.
    Description of the invention According to the invention there is provided an apparatus for the production of granules, in particular for the manufacture of pharmaceutical granules, which provides at least two functional units for at least two different process steps in the granulation process, the device comprising a modular system of buildings, the least functional the units can be assembled depending on the current process step.
    The device according to the invention is particularly suitable for the production of pharmaceutical products in which various active substances in the form of a powder are combined. Particularly advantageous is the use of the device according to the invention in the production of small amounts which do not exceed 60 l, and in particular in the production of small quantities in the minimum scale which do not exceed 30 ml. Additional applications extend to the building industry, for example in the manufacture of building materials, the plastics industry, in particular plastic granules, which are further processed by injection molding or extrusion, the food industry, in particular in the manufacture of dry foods and the cosmetics industry, in particular in the manufacture of base products such as pillows, blush or eye shadow.
    A granulate within the meaning of the invention comprises an agglomeration of powder particles, the grain size depending on the choice of granulation process. Thus, for example, in the case of moisture granulation, the starting materials or the starting substances are mixed, such as powder or a powder mixture, with a granulating liquid, the granulating liquid comprising a solvent, a solvent mixture, a solution of binder and / or a solution of adhesive substances. As a result, a doughy mass is formed, which, for example, is granulated or formed into granular grains with the aid of a sieve. The resulting grain size is exceeded by indicating the mesh size of the screen used. Usually in a sAclan granulation a grain mixture is formed with a grain size distribution, which belongs to a classic Gaussian distribution and has an average grain size between 1 p.m to 5 mm and especially preferred 5 p.m to 3 mm. by the scope of the invention denotes a functional unit, a unit in which the process step is carried out. The functional unit formed by the modular system of superstructures is then determined by the present configuration, in which the superstructures can be arranged. Thus, the device according to the invention for moisture granulation provides, for example, a mixing unit, which comprises at least one map which consists of separate buildings, for example of a rod and an open bottom, and a central cradle component, which is clamped between the bottoms. In such a vessel, the mixture can be mixed by means of a mixer, usually a stirrer. Further examples of functional units of granulation unit, dryer unit or classification unit, which according to the invention can be assembled from separate p5 buildings.
    In an embodiment according to the invention, the device comprises at least one rotatable and / or displaceable arranged plate, on which the buildings can be assembled into functional 4 units. [MaiII, receiving means can be arranged on the plate, on which the superstructures can be attachable. In order to occupy, position and release the superstructures, the receiving means can be movably arranged between at least two positions. Thus, after the uptake of at least one building, the receiving means can position it, so that the combination with further buildings on further receiving means forms a functional unit.
    One possibility of realizing such a receiving means on the plate consists in arranging at least one pin or a pointed elevation per extension on the plate. In this case, the receiving means can be designed to intervene in the recess-shaped depressions designed therefor in the buildings. Furthermore, the pins or the pointed elevations could be arranged on a movable slide, in order to accommodate buildings in one position and then be driven into an end position. Preferably at least two pins or pointed elevations are arranged per superstructure, which can be reciprocated between a receiving position and an end position. An additional possibility of realizing clever receiving means consists of occupying the buildings by means of mechanical or magnetic grippers or occupying through interlocking slots. Snap fasteners can also be used to fasten the buildings on the slab.
    In a preferred embodiment, the buildings comprise separate components, which form a reaction space for the actual process step. In this case, the structures for forming a reaction space comprise at least one duct component, such as a bottom, a filter or a screen, and at least one central component. In a preferred embodiment, the buildings comprise at least one of the following components: a bottom, which closes the reaction space in one direction; - a central component, which, for example as a cradle element, closes the reaction space on the side and possibly has a slide; a holder, which clamps the central components together with the bottom and provides access to the reaction space: In this case, the bat and the holder form the components between which, during the assembly of a vessel, a central component is clamped. The central component can then be designed as a cradle element, which is fixed between other superstructures, such as the batten and holders. For example, the cradle element may be formed by a rudder piece, which may have a round, angular or oval cross-section. Underlying the clamming action of the superstructures, such central components can additionally be loaded by a gripper, in order to guarantee a sealing effect even in the case of a superstructure change.
    Alternatively or additionally, the device may comprise one or more of the following structures, in particular the functional components: one or more screens, which allow a transition of a material Iran a first reaction space to a second reaction space without material loss and at the same time standardize the particle size distribution in the screen; one or more filters, which consist of the sieve with a very small mesh size and which hails the material back into the reaction chamber, while gas can pass at the same time; one or more mixers, in particular stirrers, which serve to mix a powder mixture or a powder mixture with granulation liquid; one or more drying, vibrating, dosing, fluidizing units, as well as combinations of have by way of example only listed buildings.
    The object of the invention is furthermore a system consisting of several devices, as described above, which are operated in parallel.
    According to the invention, there is further proposed a process for the preparation of a granulate, in which the device described above is used. The process according to the invention comprises the following steps: providing a mixture of starting materials in a first functional unit, and granulating the mixture in a second functional unit, the at least two functional units depending on the actual process step Jr composed of a modular system of buildings. Accordingly, within the scope of the invention, the device can be adapted in the course of the process to the actual process step intended for implementation. In an embodiment of the process according to the invention, the first functional unit can be fed to the preparation of the mixture at least one powder and at least one granulation liquid by means of a dosing device and mixed in the first functional unit by means of a mixer. In a further embodiment of the process, the mixture during the granulation can be sieved in a second functional unit. Thereafter, further steps may follow, in which the mixture is dried and classified into further functional units. In a final step, the granules can be filled into a storage container. Alternatively, the granulate can also be further processed directly and filled into a press matrix, in which the granulate is compressed into a final product.
    Advantages of the invention The invention enables the production of granules in a confined space. In particular, through the modular system of buildings, different units for the implementation of the current process steps are integrated in one apparatus. Darmed Jr a flexible process control possible, which can drain completely automatically. For example, the superstructures in the course of the procedure can be combined almost arbitrarily according to a type of construction principle in order to carry out the relevant process steps in a certain order. Even a parallel processing is easy to realize with the corresponding design of the apparatus.
    An additional advantage is that all the elements in the Ater process are used. As a result, no waste is formed. In addition to the container in which the granules formed are transported from the apparatus and for storage or alternatively for further processing, all the elements are fed after cleaning the apparatus again.
    Furthermore, the superstructures and thus the device according to the invention as well as the method according to the invention can be flexibly adapted to the desired process conditions. Thus, the device according to the invention and the method according to the invention can be adapted to a desired sample volume. Thus, the invention is particularly designed to process small sample volumes in the range of about ten milliliters, for example less than 30 ml. This makes it possible, for example in parameter field experiments, to create reproducible experimental conditions and at the same time save valuable sample material.
    In addition, the functional units, for example, mixing, granulating or drying units, can be adapted to the granulate intended for preparation and the starting materials used. Thus, the process according to the invention with respect to the composition, processing and sample volume can be optimally derived with the product intended for manufacture. Through a stable standardized basic process, parameters such as the homogeneous distribution of a substance in the reaction mixture can be investigated and deliberately improved, or the apparatus can be installed on a special substance mixture.
    Particularly in the field of pharmacological research of active substances, a reproducible production of granules on a laboratory scale is regularly required. Through the construction loading principle and the automation of the process, the invention can correspond to Adana requirements. This also opens up the possibility of parameter field investigations (Screening), which can be used in the search for materials, in particular active substances for new drugs, or in the optimization of parameter sets.
    In addition, the invention makes it possible, in the laboratory process, to develop processes for parallelization and through a starting number of devices to use it in production, in particular mass production. An upscaling, that is to say the transition Iran's laboratory phase to mass production, can be realized without major costs. In addition, typical scaling problems can be avoided.
    Brief Description of the Drawings The embodiments of the invention are illustrated in the figures and will be further elucidated in the following description. They show: Figure 1 an exemplary embodiment of the device according to the invention for the production of granules, wherein the building configuration is particularly suitable as a dosing and mixing unit; Figure 2 shows an embodiment of the device according to the invention in an alternative embodiment, wherein the building configuration is in particular lamped as a granulation unit; Figure 3 is an exemplary sequence of configurations of the device according to the invention in the form of a schematic flow diagram; Figure 4 is an exemplary procedure, which is possible within the framework of the overall procedure according to Figure 3 within the apparatus according to the invention; Figure a further exemplified Asked process, which can be carried out in the device according to the invention during the process according to Figure 3 and Figure 6 a further exemplified Asked process, which in the device according to the invention can be carried out during the process according to Figure 3.
    Embodiments of the invention Figure 1 shows a device 10 according to the invention with a plate 12 and various pA buildings 14, which in an exemplary configuration 16. 1 are arranged p5 the plate 12.
    The device according to the invention is particularly suitable for the production of granules by moisture granulation of a powder. Preferably, the device 10 is used for pharmaceutical products, which can be prepared on a minimum scale of less than 30 ml. In addition 9, a plate 12 is rotatably arranged to accommodate different superstructures 14 in different configurations 16.1. Furthermore, the plate 12 comprises a receiving mechanism with receiving means 18, which receives and fixes the buildings 14.
    This pick-up mechanism 18 can be realized, for example, by pairs of pins and a pair of pointed elevations, respectively, which in all cases fix or release the buildings 14 by means of stalls.
    In the embodiment of the device 10 according to the invention shown in Figure 1, three rows of receiving means 18.1, 18.2, 18.3 are arranged, between which different configurations 16 of buildings 14 can be realized. Through the rotatably arranged plate 12, it is thus possible to arrange pick-ups 14 between the pick-up means 18.1 and 18.2, turn the plate approximately in 1800 and then insert further structures 14 between the pick-up means 18.2 and 18.3.
    The buildings 14 Jr within the framework of the device according to the invention 10 are designed as details, with which a reaction space 32 is created. In the embodiment shown in Figure 1 exemplified, the buildings 14 include bottom 20, holder 24, filter 22, screen 26, pipe piece 28 and at least one vessel for the end product 30, which are placed in an area adjacent to the plate 12. In other embodiments, depending on the For the procedure intended for implementation, additional buildings 14 in different numbers and different designs are provided.
    In Figure 1, the pawls 14 are assembled into a configuration 16.1, the configuration 16.1 comprising a bottom 20a and a rudder piece 28a between the receiving means 18.1 and 18.2. Such a configuration 16. 1 is formed in that the receiving means 18.1 and 18.2 in all cases occupy a holder 24a and a bottom 20a. The receiving means 18 are then preferably designed as a pair of pins or a pair of pointed elevations, for example in the plate 12 and corresponding recesses in the buildings 14, which with reference to Figure 1 after movement of the corresponding receptacles 14 are moved in the vertical direction, to clamp the central component. , has the rudder piece 28a. Alternative designs 10 of the receiving means 18 include mechanical or magnetic grippers, interlocking slots or snap closures.
    To create a reaction space 32 on the plate 12, the pipe piece 28a is inserted between the bottom 20a and the holder 24a, while the receiving means 18.1 and 18.2 are in the release position 32. After the pipe piece 28a has been inserted between the superstructures 14, the holder 24a and the bottom 20, including the pipe piece 28a between these, the receiving means 18.1 and 18.2 being transferred to a fixing position 34. For gripping the rudder piece 28a, a gripper can likewise be used, which in addition to the clamping action of the structures 20a, 24a centrally locks the rudder piece 28a. This has the advantage that a superstructure change can be made and the sealing effect of the superstructures 14 is also given.
    Through the modular construction of the device 10 according to the invention shown, for example, in Figure 1, a reaction space 32 is created, which is accessible via the holder 24a, for adding reaction materials, such as powder and granulation liquid. Furthermore, elements such as an overhead stirrer for homogenization and for supporting screening processes via the holder 24a can be introduced into the reaction space 32. Also a replacement of holder 24a with, for example, a second bottom 20 allows a transformation of the reaction space 32. For example, in the exchange of the holder 24 a second bottom 20 a rod reaction chamber 32 is created, which can be rotated without material loss. Thereby, the device according to the invention can be variably adapted to the actual reaction steps, in particular for moisture granulation, so that all processes are integrated in a device 10 and the process steps Jr are feasible in the narrowest spaces.
    Figure 2 shows the device according to the invention 10 according to figure 1, wherein an alternative configuration 16.2 on the plate 12 Jr 5 is shielded.
    Unlike Figure 1, in Figure 2 the bottom 20a is replaced by the screen 26a, which is inserted between the receiving means 18.1 and 18.2 next to the holder 24a and the pipe piece 28a. Furthermore, an overlying stirrer 38 is inserted through an opening in the holder 24a into the formed reaction space 32. Next to the reaction space 32 between the receiving means 18.1 and 11 18.2, a further pipe piece 28b and a further bottom 20b are arranged between the receiving means 18.2 and 18.3.
    The arrangement foil, in order to go from the configuration 16.1 shown in Figure 1 to the configuration 16 shown in Figure 2, comprises several exchange steps for taxiing the buildings 14. Such a procedure is shown in Figure 3.
    Figure 3 shows exemplified in a flow chart 48 the configuration of the p5 buildings 14 during a granulation process.
    For better understanding of the flow chart shown in Figure 3 for carrying out a granulation process, the individual building components are provided with letters, which in all cases denote the initial letters of the designated building components. If a component is used in several embodiments, these are numbered by their order. B bottom denotes B bottom G pipe piece or vessel cradle, H holder, D dosing device R stirrer, S screen, F filter, T drying device and V vibration device.
    In a first step 40. 1 of the flow diagram shown exemplified in Figure 3, the configuration 16 shown in Figure 1 is first formed. To this end, a bottom B is fixed by the receiving means 18.2, then a pipe piece G1 is inserted in the area above the bottom by means of, for example, a gripper and finally a holder H is occupied by the receiving means 18.1. The pipe section G1 is clamped by the process of the receiving means between the bottom B1 and the holder H1 and p5 s5 set, a reaction space 32 is created. Furthermore, the pipe section G1 can for example be additionally locked by means of a gripper (not shown),
    In a second step 40.2, a dosing device D, for example a pipette, a screw dosing device, a vibration dosing device, a knitting needle, or similar devices for dosing volumes at a minimum scale, is inserted into the holder H. The dosing device D thereby directs the starting materials for granulation, such as a powder and a granulation liquid, to the reaction chamber, whereby the individual components can in all cases be supplied 12 separated from each other with different dosing devices or with a dosing device.
    In a step 40. 3, the dosing device D and a mixer 38, such as an overlying stirrer, are deposited over the holder H into the reaction chamber 32 and the starting substances are mixed. In a next step 40.4 the stirrer R and the holder H are finally removed and instead of the holder H an additional bottom B2 is inserted in the configuration of the device 10. [Main the holder is placed away in its original position outside the plate 12 and released by the receiving elements 18.2. Instead, the receiving elements 18.2 occupy a bottom B2 and are displaced from the release position into the locking position, whereby a closed reaction space 32 formed by the ram bottoms B1, B2 and the rudder piece G1 is formed.
    In the configuration completed after step 40.4, the plate can be rotated 180 °, so that the reaction space 32 formed by the ram bottoms B1, B2 and the pipe piece G1 is rotated from the upper area 44 into the lower area 46. After the rotation, the receiving means 18.2 and 18.3, as shown in Figure 1, in the area 44 and can accommodate additional buildings 14. Thus, first the bottom B1 is released from the receiving means 18.2 to its original position outside the plate 12. Then the receiving means 18.2 occupies a sieve Si and locks the pipe piece G1 by displacing the receiving means 18.2. in the fixation position. Complementing the screen 51, in step 40.6, a pipe piece G2 and a further bottom B3 are inserted between the receiving means 18.1 and 18.2, in order to create an additional reaction space 36.
    In step 40.7, the plate 12 is rotated 42.2 and the bottom B2 of the receiving means 18.1 is replaced with a holder H, which in step 40.8 receives a stirrer R, as an overlying stirrer. In this step, the mixture prepared in 40.3 is sieved from the reaction chamber G1 into the reaction chamber G2. In step 40.9, after the sieving, the holder H, the pipe piece G1 as well as the sieve Si are removed and replaced in step 40.10 by a filter F1 in the receiving means 18.2. Thereafter, a rotation 42.3 takes place, which brings the pick-up means 18.1 into the area 44. In step 40.11, a further replacement of the bottom B3 with a filter F2 takes place. In addition, the take-up means 18.1 first enter a release position, the bottom B3 is released, the filter F2 is taken up and transits again in a fixing position. This gives a reaction space formed by the filters F1, F2 and the pipe section G2. After step 40.11, a rotation 42.4 takes place again through which the pick-up means 18.3! Cars into the upper area 44. It must be pointed out that the filters for the screened mixture are impermeable and the material is only kept in the reaction chamber, while gases can pass at the same time. The filters F1, F2 accordingly have a smaller mesh size than the screen. Thus, a drying in step 40.12 can be realized, in that a dryer T, such as a heating flux, is inserted in the area of the filter F2 or alternatively in the area of the filter F1 or in the area of the ram filters. The reaction space formed by the two filters F1, F2 thus constitutes a fluidization unit which is permeable to gases. In this way, the material can be fluidized with hot air and dried at the same time. Alternatively, the fluidization may also be used to homogenize the substance mixture.
    The drying is accompanied in step 40.13 by a further configuration change for the classification of the granules produced. In addition, the filter F1 is replaced with a screen S2 in the receiving device 18.2, a pipe piece G3 in the area 44 is inserted and finally terminated through a bottom B2 at the receiving elements 18. 3.
    Darpa follows a new rotation in 180 ° 42.5, s5 that the classification of the granulate can take place through the sieve S2. To support the process in step 40.14, a vibrator V is arranged in the area 46, which by shaking supports the flow of the granulate through the screen S2. Furthermore, the filter F2 and the rudder piece G2 are removed after the classification. In step 40.15, the final product in the vessel is further removed from the rudder piece G3 and bottom B2.
    In a final step 40.16 after a rotation in 1800, the device 10 for the production of granules is returned in the original configuration of step 40.1. In addition, the bottom B2 is deposited and the bottom B1 is held in the fixing position by the receiving elements 18.2.
    Figures 4 to 6 show further embodiment possibilities for the separate process steps Ater schematically exemplified. Figure 4 shows, for example, further details with respect to that of the screening procedure in steps 40.13 and 40. The ash-filled process is shown, wherein the pipe piece 28 further comprises a slide 50. In this case, the pipe piece 28 at the end terminated by the slide 50 is equipped with a screen. 26.1 the pipe piece 28, the starting materials may be such as one or more powders 52, which in a subsequent step are mixed with a granulation liquid. [Main can be used a dosing device 53 and an overlying stirrer 51, which produces a mixture 54. led last step, the thus granulated composition with the aid of overlying stirrer 51 can by passing the slide 50 pass through the screen 26. To channel the flow of the granulate 56, a funnel 58 may further be provided, so that the granulate 56 lands on a catch surface 60.1 Fig. 5 is an alternative embodiment to the latter step 5sconducted, the granulate being channeled through the funnel 58 in a press die 62. Thereby the press die serves for the production of e.g. tablet form by dry pressing.
    Figure 6 shows a further embodiment, which instead of the slide 50 in Figures 4 and 5 has a pipette device 64 for transferring the finished granulate 54 from the feed 28 into the press matrix 62. In this case, the starting substances for the granulate are first added, for example a powder and a granulation liquid. through the dosing device 53. These are mixed by means of the overlying stirrer 51 in the cadet, so that the granulate 54 is formed. In the next step, the granulate 54 is transferred from the vessel 28 through a pipette 64 into a press matrix 62. This has the advantage the present 30 ml can be immediately dispensed into a mold, to produce corresponding tablet forms.
    The device 10 according to the invention for the production of granules 56 offers a flexible and extremely space-saving possibility for the processing of, for example, chemical pharmaceutical products in high-resolution development. In addition, cleaning and maintenance costs through the device 10 according to the invention, in particular for laboratory use, can be fully automated, in order to produce formulations of smaller size and at the same time enable a screening.
    The invention is not limited to the embodiments described and the clan aspects emphasized. Rather, in the areas specified by the dependency requirements, a number of variants are possible within the framework of the professional trade. 16
    权利要求:
    Claims (13)
    [1]
    An apparatus (10) for producing a granulate (56), which provides at least two functional units (16.1, 16.2) for at least two different process steps (40.1 to 40.16) in the granulation process, characterized in that the device (10) comprises a modular system of superstructures (14, B, H, G, S, F), of which the least tv5 functional units (16.1, 16.2) can be assembled depending on the current process step (40.1 to 40.16).
    [2]
    Device (10) according to claim 1, characterized in that the functional unit (16.1, 16.2) is determined by the current configuration (16.1, 16.2), in which the buildings (14, B, H, G, S, F) Jr are arranged .
    [3]
    Device (10) according to any one of claims 1 or 2, characterized in that the device (10) for assembling the superstructures (14) into functional units (16.1, 16.2) comprises at least one rotatably and / or displaceably arranged plate (12).
    [4]
    Device (10) according to any one of claims 1 to 3, characterized in that the plate (12) comprises receiving means (18, 18.1, 18.2, 18.3), on which the buildings (14) are fixed.
    [5]
    Device (10) according to any one of claims 1 or 4, characterized in that the receiving means (18, 18.1, 18.2, 18.3) are displaceable between at least two positions (32, 34) for receiving, positioning and releasing the buildings (14, B , H, G, S, F).
    [6]
    Device (10) according to any one of claims 1 to 5, characterized in that the buildings (14, B, H, G, S, F) comprise individual components, which form a reaction space (32, 36) for the actual process step (40.1). to 40.16).
    [7]
    Device (10) according to any one of claims 1 to 6, characterized in that the buildings (14, B, H, G, S, F) for the formation of a reaction space (32, 36) comprise at least one duck component (B, F, S) and at least one central component (G). 17
    [8]
    Device according to any one of claims 1 to 7, characterized in that the device (10) comprises one or more of the following functional components: a dosing unit (D), a screen (S), a filter (F), a mixer (R) , a dryer unit (T), a fluidization unit (F) and a vibration unit (V).
    [9]
    System consisting of several devices (10) according to any one of claims 1 to 8, which are operated in parallel.
    [10]
    Process for the preparation of a granulate (56) using the device (10) according to any one of claims 1 to 8 with the following steps: 1. providing (40.2, 40.3) a mixture of starting substances in a first functional unit (16.1) , and 2. granulation of the mixture in a second functional unit (16.2), characterized in that the at least tv5 functional units (16.1, 16.2) depending on the current process step (40.1 to 40.16) are composed of a modular system of pA buildings (14, B, H, G, S, F).
    [11]
    Method according to claim 10, characterized in that in the preparation of the mixture, the first functional unit (16.1) is supplied with at least one powder and at least one granulation liquid through a dosing device (D) and mixed through a mixer (R).
    [12]
    A method according to any one of claims 10 or 11, characterized in that the mixture is sieved during the granulation in a second functional unit (16.2).
    [13]
    Process according to any one of claims 10 to 12, characterized in that the mixture is dried and classified (40.12 to 40.15) in at least one further functional unit. R. 344008 116
    类似技术:
    公开号 | 公开日 | 专利标题
    DE69812154T2|2004-01-08|DEVICE AND METHOD FOR SEPARATING LIQUID AND SOLID PHASES IN ORGANIC SOLID PHASE SYNTHESIS
    US6881363B2|2005-04-19|High throughput preparation and analysis of materials
    TWI313189B|2009-08-11|Charging device for tube bundle reactors and method for operating the same
    US6832737B2|2004-12-21|Parallel sizing dosing and transfer assembly and method of use
    US7980803B2|2011-07-19|System for releasing bulk material, and container having such a bulk-material-releasing system
    JP2007536068A|2007-12-13|Disposable flexible container
    US20040110636A1|2004-06-10|Methods for mechanical treatment of materials such as catalysts
    SE1350695A1|2013-12-21|Granulation device and method
    US7147109B2|2006-12-12|Sieve device for screening solid material
    CN202315779U|2012-07-11|Powder homogenizing bin
    DE3723004C2|1990-06-07|
    CN109529704A|2019-03-29|The vertical conglomerate integration flavoring powder production equipment of ox horn ribbon and production technology
    WO2001084108A2|2001-11-08|Automated sample collection workstation
    FI78402C|1989-08-10|ANORDINATION FOR FRAMSTAELLNING AV FLERKOMPONENTSBLANDNINGAR.
    CN202036956U|2011-11-16|Premixing device
    US3557267A|1971-01-19|Method for compacting particulate material
    CN205463119U|2016-08-17|A equipment for sieving mix metallurgical material
    CN104394974B|2017-09-19|The equipment with scalable for handling granular materials
    RU2315535C1|2008-01-27|Line for obtaining of extruded products
    RU2229918C2|2004-06-10|Method of desublimation of solid substances and a device for its realization
    CN213813096U|2021-07-27|Be used for soil sample to mix appearance division device fast
    CN213855578U|2021-08-03|Microbial fertilizer is dried and screening integration equipment
    CN213761854U|2021-07-23|High-flux preparation microsystem for iron-carbon catalyst
    CN211027060U|2020-07-17|Rotary vibrating screen for pesticide production
    CN211943795U|2020-11-17|Double-bin feeding and mixing device
    同族专利:
    公开号 | 公开日
    GB201304563D0|2013-04-24|
    SE537343C2|2015-04-07|
    GB2503307A|2013-12-25|
    DE102012210362A1|2013-12-24|
    GB2503307B|2018-10-24|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE4318471A1|1993-06-03|1994-12-08|Thomae Gmbh Dr K|One-pot mixer-granulator-dryer|
    PL178091B1|1995-07-07|2000-02-29|Suomen Rehu Oy|Apparatus for producing granules, granule producing method and granulated material obtained thereby|
    AU7333101A|2000-07-07|2002-01-21|Symyx Technologies Inc|Methods and apparatus for mechanical treatment of materials such as catalysts|
    FI20012034A|2001-10-19|2003-04-20|Ariacon Oy|Multifunctional fluid handling equipment and method for processing material in a fluid handling equipment|
    DE10234229B4|2002-07-27|2005-09-01|Berstorff Gmbh|granulator|
    DE102004035462A1|2004-07-22|2006-03-16|Ehrfeld Mikrotechnik Bts Gmbh|Apparatus and method for the continuous performance of chemical processes|
    US20090087483A1|2007-09-27|2009-04-02|Sison Raymundo A|Oral dosage combination pharmaceutical packaging|
    CN201437080U|2009-07-31|2010-04-14|上海申德机械有限公司|Modular granulation production line for granular product production|DE102017207064A1|2017-04-27|2018-10-31|Robert Bosch Gmbh|granulation|
    法律状态:
    2019-01-29| NUG| Patent has lapsed|
    优先权:
    申请号 | 申请日 | 专利标题
    DE102012210362A|DE102012210362A1|2012-06-20|2012-06-20|Apparatus and method for granulation|
    [返回顶部]